Frozen Red Blood Cells (FRBCs) are an FDA-licensed product which allow for cryopreservation
of red blood cells for up to 10 years. FRBCs were first used by the military in
a theater of war in 1966 in the Republic of South Vietnam. Current technology allows
for frozen red cells to be thawed; the resultant product has and a 14-day shelf
life . FRBCs are available for use in hospitals stateside, overseas and pre-positioned
aboard US Navy ships. FRBCs have been shown equally effective as normal packed red
blood cells (PRBCs) in their ability to deliver oxygen to tissues and organs. A
noted advantage of frozen red cells over packed red cells is a significant reduction
of white blood cells and other biologically active substances known to contribute
to transfusion reactions. See below for further information and research on the
use of frozen blood.
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Red Blood Cells (PDF, 190kb)
Frozen Red Blood Cells (FRBC) have long been an FDA-licensed product manufactured
by military donor centers for use in contingency operations. Traditionally employed
in locations where it would be difficult to provide a large inventory of FDA-licensed
liquid red cell units, frozen blood can be used by hospitals both stateside and
overseas. Unfortunately, this resource has gone largely unused due to a variety
of factors; primarily a lack of information about the product and its uses. [Read more...]
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Transfusion of Cryopreserved Packed Red Blood Cells Is Safe and Effective After Trauma: Prospective Randomized Trial
Annals of Surgery. 2015 Sept.; 262(3): 426-433.
Experiences with frozen blood products in the Netherlands military.
Transfus Apher Sci. 2006 Jun;34(3):289-98. Epub 2006 Jul 3.
Successful in vivo recovery and extended storage of additive solution (AS)-5
red blood cells after deglycerolization and resuspension in AS-3 for 15 days with
an automated closed system.
Transfusion. 2007 Apr; 47(4):680-6.
Extended storage of AS-1 and AS-3 leukoreduced red blood cells for 15 days after
deglycerolization and resuspension in AS-3 using an automated closed system.
Transfusion. 2004 Nov; 44(11):1656-62.
Cryopreserved deglycerolized blood is safe and achieves superior
tissue oxygenation compared with refrigerated red blood cells
J Trauma Acute Care Surg. 2013 Feb;74(2):371-6
Fabricant L, Kiraly L, Wiles C, Differding J, Underwood S, Deloughery T, Schreiber